Different types of consent are used to obtain human biospecimens for future research. This variation has resulted in confusion regarding what research is permitted, inadvertent constraints on future research, and research proceeding without consent. The National Institutes of Health Clinical Center's Department of Bioethics held a workshop to consider the ethical acceptability of addressing these concerns by using broad consent for future research on stored biospecimens. Multiple bioethics scholars, who have written on these issues, discussed the reasons for consent, the (...) range of consent strategies, and gaps in our understanding, and concluded with a proposal for broad initial consent coupled with oversight and, when feasible, ongoing provision of information to donors. This article describes areas of agreement and areas that need more research and dialogue. Given recent proposed changes to the Common Rule, and new guidance regarding storing and sharing data and samples, this is an important and tim.. (shrink)

Controversy persists over the ethics of compensating research participants and providing posttrial benefits to communities in developing countries. Little is known about residents' views on these subjects. In this study, interviews about compensation and posttrial benefits from a hypothetical HIV vaccine trial were conducted in Uganda’s Rakai District. Most respondents said researchers owed the community posttrial benefits and research compensation, but opinions differed as to what these should be. Debates about posttrial benefits and compensation rarely include residents' views like these, (...) but future ones should. (shrink)

Although informed consent is important in clinical research, questions persist regarding when it is necessary, what it requires, and how it should be obtained. The standard view in research ethics is that the function of informed consent is to respect individual autonomy. However, consent processes are multidimensional and serve other ethical functions as well. These functions deserve particular attention when barriers to consent exist. We argue that consent serves seven ethically important and conceptually distinct functions. The first four functions pertain (...) principally to individual participants: (1) providing transparency; (2) allowing control and authorization; (3) promoting concordance with participants' values; and (4) protecting and promoting welfare interests. Three other functions are systemic or policy focused: (5) promoting trust; (6) satisfying regulatory requirements; and (7) promoting integrity in research. Reframing consent around these functions can guide approaches to consent that are context sensitive and that maximize achievable goals. (shrink)

California is a landmark setting for studying produce recovery efforts and policy implications because of its global relevance in agricultural production, its complex network of food recovery organizations, and its environmental and public health regulations. Through a series of focus groups with organizations involved in produce recovery (gleaning organizations) and emergency food operations (food banks, food pantries), this study aimed to deepen our understanding of the current produce recovery system and determine the major challenges and opportunities related to the produce (...) recovery system. Operational and systematic barriers to produce recovery were highlighted by both gleaning and emergency food operations. Operational barriers, such as the lack of appropriate infrastructure and limited logistical support were found to be a challenge across groups and were directly tied to inadequate funding for these organizations. Systematic barriers, such as regulations related to food safety or reducing food loss and waste, were also found to impact both gleaning and emergency food organizations, but differences were observed in how each type of regulation impacted each stakeholder group. To support the expansion of food recovery efforts, participants expressed need for better coordination within and across food recovery networks and more positive and transparent engagement from regulators to increase understanding of the specifics of their unique operational constraints. The focus group participants also provided critiques on how emergency food assistance and food recovery are inscribed within the current food system and for longer term goals of reducing food insecurity and food loss and waste a systematic change will be required. (shrink)

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: What key (...) questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

This book offers a unified collection of published and unpublished papers by Robert Audi, a renowned defender of the rationalist position in ethics. Taken together, the essays present a vigorous, broadly-based argument in moral epistemology and a related account of reasons for action and their bearing on moral justification and moral character. Part I details Audi's compelling moral epistemology while Part II offers a unique vision of ethical concepts and an account of moral explanation, as well as a powerful (...) model of moral realism. Part III extends this account of moral explanation to moral responsibility for both actions and character and to the relation between virtue and the actions that express it. Part IV elaborates a theory of reasons for action that locates them in relation to three of their traditionally major sources: desire, moral judgment, and value. Clear and illuminating, Audi's introduction outlines and interconnects the self-contained but cumulatively arranged essays. It also places them in relation to classical and contemporary literature, and directs readers to large segments of thematically connected material spread throughout the book. Audi ends with a powerfully synthetic final essay. (shrink)

Preface 9 PART I: RELIGIOUS, SCIENTIFIC, AND PHILOSOPHICAL BACKGROUND Introduction to Part I 19 1. The Bible 27 2. Natural Theology 33 William Paley 3. On the Origin of Species 38 Charles Darwin 4. Objections to Mr. Darwin’s Theory of the Origin of Species 65 Adam Sedgwick 5. The Origin of Species 73 Thomas H. Huxley 6. What Is Darwinism? 82 Charles Hodge 7. Darwinism as a Metaphysical Research Program 105 Karl Popper 8. Karl Popper’s Philosophy of Biology 116 Michael (...) Ruse 9. Human Nature: One Evolutionist’s View 136 Francisco Ayala 10. Universal Darwinism 158 Richard Dawkins PART II: CREATION SCIENCE AND THE McLEAN CASE Introduction to Part II 187 11. The Creationists 192 Ronald L. Numbers 12. Creation, Evolution, and the Historical Evidence 231 Duane T. Gish 13. Witness Testimony Sheet: McLean v. Arkansas Board of Education 253 Michael Ruse 14. United States District Court Opinion: McLean v. Arkansas Board of Education 279 Judge William R. Overton 15. The Demise of the Demarcation Problem 312 Larry Laudan 16. Science at the BarùCauses for Concern 331 Larry Laudan 17. Pro Judice 337 Michael Ruse 18. More on Creationism 345 Larry Laudan 19. Commentary: Philosophers at the BarùSome Reasons for Restraint 350 Barry R. Gross PART III: INTELLIGENT DESIGN CREATIONISM AND THE KITZMILLER CASE Introduction to Part III 369 20. But Isn’t It Creationism? The Beginnings of "Intelligent Design" in the Midst of the Arkansas and Louisiana Litigation 377 Nick Matzke 21. What Is Darwinism? 414 Phillip E. Johnson 22. Is It Science Yet? Intelligent Design, Creationism, and the Constitution 426 Matthew Brauer, Barbara Forrest, and Steven G. Gey 23. Kitzmiller v. Dover Area School District Expert Witness Testimony 434 Michael Behe 24. Kitzmiller v. Dover Area School District Expert Report 456 Robert T. Pennock 25. A Step toward the Legalization of Science Studies 485 Steve Fuller 26. What Is Wrong with Intelligent Design? 495 Elliott Sober 27. United States District Court Memorandum Opinion: Kitzmiller, et al. v. Dover Area School District, et al. 506 Judge John E. Jones II 28. Can’t Philosophers Tell the Difference between Science and Religion? Demarcation Revisited 536 Robert T. Pennock. (shrink)

The understanding of appropriate ethical protections for participants of biomedical research has not been static. It has evolved over time, with the evolution of biomedical research as well as social values. Since World War II, there have been four major paradigms of research and research oversight operative in the United States. These paradigms incorporate different values and provide different approaches to research oversight and the protection of research participants.

In this paper we examine the ethical implications of emerging Nanotechnologically Enhanced Combat Systems (or 'NECS'). Through a combination of materials innovation and biotechnology, NECS are aimed at making combatants much less vulnerable to munitions that pose a lethal threat to soldiers protected by conventional armor. We argue that increasing technological disparities between forces armed with NECS and those without will exacerbate the ethical problems of asymmetric warfare. This will place pressure on the just war principles of jus in bello, (...) by encouraging the resort to tactics that either (i) make it more difficult to respect these principles or (ii) directly violate them, by virtue of attacking non-combatants or creating disproportionate numbers of casualties without a clear military goal. (shrink)

Every pharmacist, aware or not, is constantly making ethical choices. Sometimes these choices are dramatic, life-and-death decisions, but often they will be more subtle, less conspicuous choices that are nonetheless important. Assisted suicide, conscientious refusal, pain management, equitable and efficacious distribution of drug resources within institutions and managed care plans, confidentiality, and alternative and non-traditional therapies are among the issues that are of unique concern to pharmacists. One way of seeing the implications of such issues and the moral choices they (...) pose is to look at the experiences of practitioners and the kinds of choices they have had to make in situations typically faced by pharmacists. This book is a collection of those situations based on the real experiences of practicing pharmacists. The use of case studies in health care ethics is not new, but in pharmacy it is. This text is an important teaching tool that will help pharmacy students and pharmacists address the increasing number of ethical problems arising in their profession. It is not merely a compilation of cases, but rather is organized for the systematic study of applied ethics. Part I shows how to distinguish ethical problems from other kinds of evaluative judgments and examines the sources of values in pharmacy, posing basic questions about the meaning and justification of ethical claims. Part II explores the basic principles of ethics as they have an impact on pharmacy. Specific cases from clinical settings present in a systematic way the various questions raised by each of the major ethical principles -- benefiting the patient, distributing resources justly, respecting autonomy, dealing honestly with patients, keeping promises of confidentiality, and avoiding harm. Part II examines some of the special problems of contemporary pharmacy such as the linkages between pharmaceutical care and professional practice, human experimentation, reproductive issues, genetic technology, death and dying, and mental health. (shrink)

This chapter contains section titled: I empathy as the foundation of moral awareness II intelligible, empirical, and acquired character III humanity's sublime anguish Notes Further Reading.

This book is a unique contribution to the philosophy of religion. It offers a comprehensive discussion of one of the most famous arguments for the existence of God: the ontological argument. The author provides and analyses a critical taxonomy of those versions of the argument that have been advanced in recent philosophical literature, as well as of those historically important versions found in the work of St Anselm, Descartes, Leibniz, Hegel and others. A central thesis of the book is that (...) ontological arguments have no value in the debate between theists and atheists. There is a detailed review of the literature on the topic (separated from the main body of the text) and a very substantial bibliography, making this volume an indispensable resource for philosophers of religion and others interested in religious studies. (shrink)

Several studies conducted in the 1970's by western analysts concluded that Buddhism is the main obstacle to economic development in Thailand. This view typifies the reasoning of mainstream modernization and development practices in Third World countries. Yet in recent years, Post World War II policies based upon the goal of modernization have been under attack for the environmental disasters they have generated, for their failure to improve human conditions where they have been implemented, and for their assumption that the western (...) world's high levels of production and consumption are superior to all other socio-economic possibilities. This dissertation focuses on Buddhist community and environmental action as a response to the hardships generated by modernization, and the ethical and spiritual system on which this action is based, especially as demonstrated by Thailand's forest monks. ;Chapter 1 examines traditionally accepted views of Buddhist ethics, the background against which new environmental interpretations emerge. Chapter 2 surveys the present trend of Buddhist social action, the application of Buddhist philosophy to contemporary social issues. Socially-engaged Buddhism is also considered with a view to its scriptural justification. Chapter 3 explores both the ethics and social action of Buddhism with specific reference to the conservation of nature. ;At this point in the modernization of Thailand, poverty is growing in rural areas, compounded by increasing drought and environmental adversity. At the same time, expanded corporate and governmental control over arable land and forests assumes command of the nation's remaining natural resources. Chapter 4 discusses this recent history. Chapter 5 concentrates on Thailand's conservationist forest monks, their ethical philosophy, the social and natural environments they are endeavoring to preserve or recover, and their work with villagers whose well-being is at stake. ;The concluding chapter investigates the western model of economic development, criticizing its universalizability, its underlying values, and its outcomes. I argue that the challenge to contemporary economic practices and lifestyles represented by the conservationist forest monks' revitalization of Buddhist tradition offers Thailand's rural poor the potential for a more satisfying and beneficial way of life. (shrink)

The purpose of this introduction is to give a rough overview of the discussion of the formalization of arguments, focusing on deductive arguments. The discussion is structured around four important junctions: i) the notion of support, which captures the relation between the conclusion and premises of an argument, ii) the choice of a formal language into which the argument is translated in order to make it amenable to evaluation via formal methods, iii) the question of quality criteria for such formalizations, (...) and finally iv) the choice of the underlying logic. This introductory discussion is supplemented by a brief description of the genesis of the special issue, acknowledgements, and summaries of each article. (shrink)

Originally published in 1967. An introduction to the literature of nonstandard logic, in particular to those nonstandard logics known as many-valued logics. Part I expounds and discusses implicational calculi, modal logics and many-valued logics and their associated calculi. Part II considers the detailed development of various many-valued calculi, and some of the important metathereoms which have been proved for them. Applications of the calculi to problems in the philosophy are also surveyed. This work combines criticism with exposition to form a (...) comprehensive but concise survey of the field. (shrink)

_First Philosophy: Knowledge and Reality_ brings together classic and ground-breaking readings on epistemology and the philosophy of science. Andrew Bailey’s highly regarded introductory anthology has been revised and updated in this new edition. The comprehensive introductory material for each chapter and selection remains, and new sections on philosophical puzzles and paradoxes and philosophical terminology have been added. New readings include Edmund Gettier on justified true belief, Wesley Salmon on induction, and Helen Longino on feminist science.

The soul is an explanatory principle of Aristotle’s natural science, accounting both for the fact that living things are alive as well as for the diverse natural attributes that belong to them by virtue of being alive. I argue that the explanatory role of the soul in Aristotle’s natural science must be understood in light of his view, stated in a controversial passage from Parts of Animals (645b14–20), that the soul of a living thing is a “complex activity” of its (...) organic body. This paper explores the role of this “complex activity” model of soul in Aristotle’s study of soul in De Anima. I argue, first, that the model has its origins in De Anima II.4, where Aristotle argues that living things do all they do by nature for the sake of a single, teleologically primary end. I argue further that Aristotle uses this model to account for the psychological attributes naturally present in living things, including their capacities for vital activities like nutrition, reproduction, and perception, and that this is the task to which Aristotle devotes the obscure final chapters of De Anima III. (shrink)

Some rules seem more important than others. The moral rule to keep promises seems more important than the aesthetic rule not to wear brown with black or the pool rule not to scratch on the eight ball. A worrying number of metaethicists are increasingly tempted to explain this difference by appealing to something they call “authoritative normativity” – it’s because moral rules are “authoritatively normatively” that they are especially important. The authors of this chapter argue for three claims concerning “authoritative (...) normativity”: (1) that motivation for it originates in a parochial conception of “normative flavours”; (2) that arguments against alternative ways of explaining e.g., morality’s importance are overblown; and (3) that there are strong reasons against theorizing in terms of “authoritative normativity”. The overarching aim is not to show that “authoritative normativity” is incoherent or entirely unmotivated. Rather, it is to discuss some of “authoritative normativity’s” deeper commitments to correct the impression that is it largely benign or that it is entailed by familiar and popular “metanormative” positions. Authoritative normativity, it seems to us, is a solution in search of a problem. (shrink)

Neo-teleology is the two part thesis that, e.g., (i) we have hearts because of what hearts are for: Hearts are for blood circulation, not the production of a pulse, so hearts are there--animals have them--because their function is to circulate the blood, and (ii) that (i) is explained by natural selection: traits spread through populations because of their functions. This paper attacks this popular doctrine. The presence of a biological trait or structure is not explained by appeal to its function. (...) To suppose otherwise is to trivialize natural selection. (shrink)

The first part of this survey article presented a cartography of some of the more extensively studied forms of multisensory processing. In this second part, I turn to examining some of the different possible ways in which the structure of conscious perceptual experience might also be characterized as multisensory. In addition, I discuss the significance of research on multisensory processing and multisensory consciousness for philosophical debates concerning the modularity of perception, cognitive penetration, and the individuation of the senses.

This chapter contains section titled: I universal subjectivity II the world as will III the Two‐Tiered objectication of the will: Platonic ideas and Spatio‐Temporalindividuals Notes Further Reading.

This essay argues that aristotle's doctrine of nominal definition is his semantic theory for natural-Kind terms. It offers a new interpretation of that doctrine. On this interpretation nominal definitions are initial working theoretical accounts of natural kinds which serve as starting points for scientific inquiry. As such, Nominal definitions have existential import. They make an implicit reference to the most familiar actual instances of the kinds they define and they define the essences of those kinds by reference to those instances. (...) Nominal definitions are, Thus, Accounts of real essences as much as real definitions. They are initial incomplete accounts of such essences and it is as such that they explicate the meanings of (natural-Kind) terms. (shrink)

Originally published in French in seven volumes, _Cosmopolitics_ investigates the role and authority of the sciences in modern societies and challenges their claims to objectivity, rationality, and truth. _Cosmopolitics II_ includes the first English-language translations of the last four books: _Quantum Mechanics: The End of the Dream, In the Name of the Arrow of Time: Prigogine’s Challenge, Life and Artifice: The Faces of Emergence, _and_ The Curse of Tolerance. _ Arguing for an “ecology of practices” in the sciences, Isabelle Stengers (...) explores the discordant landscape of knowledge derived from modern science, seeking intellectual consistency among contradictory, confrontational, and mutually exclusive philosophical ambitions and approaches. For Stengers, science is a constructive enterprise, a diverse, interdependent, and highly contingent system that does not simply discover preexisting truths but, through specific practices and processes, helps shape them. Stengers concludes this philosophical inquiry with a forceful critique of tolerance; it is a fundamentally condescending attitude, she contends, that prevents those worldviews that challenge dominant explanatory systems from being taken seriously. Instead of tolerance, she proposes a “cosmopolitics” that rejects politics as a universal category and allows modern scientific practices to peacefully coexist with other forms of knowledge. (shrink)

This chapter contains section titled: I universal subjectivity II the world as will III the Two‐Tiered objectication of the will: Platonic ideas and spatio‐temporalindividuals Notes Further Reading.

This chapter contains section titled: I a universal will without purpose II the purposelessness of schopenhauer's Thing‐in‐Itself III life as embittering: Schopenhauer and buddhism Notes Further Reading.

This chapter contains section titled: I the world's essence: Rational or irrational? II labor, imprisonment, and christianity III the world as will and representation and“Self‐Consciousness” in hegel's phenomenology Notes Further reading.

This chapter contains section titled: I the Rejection of a Mind‐Independent reality II kant's theory of perception III kant's use of the term“object” IV the logic of manifestation Notes Further Reading.

This chapter contains section titled: I the question of life's value II funereal imagery and nietzsche's theory of tragedy III schopenhauer's moral awareness and eternal recurrence IV the eternalistic illusion of supreme health V nietzsche's madness and eternalistic consciousness Notes Further Reading.

This chapter contains section titled: I the quest for absolute value II what the philosophical investigations cannot say Notes Further Reading.

This chapter contains section titled: I the possibility of the denial‐of‐the‐will II christian quietism, yogic ecstasy, and buddhist enlightenment III asceticism and spiritual purication Notes Further Reading.

This chapter contains section titled: I platonic ideas and aesthetic experience II artistic genius and the communication theory of art III the hierarchy of the visual and verbal arts IV tragedy and sublimity V music and metaphysical experience Notes Further Reading.

This chapter contains section titled: I the Unsettled Years: 1788–1831 II the Stable Years: 1833–1860 Further Reading.

This chapter contains section titled: I the Root of All Explanation II the Four Basic Forms of Explanation Notes Further Reading.

Multisensory processing encompasses all of the various ways in which the presence of information in one sensory modality can adaptively influence the processing of information in a different modality. In Part I of this survey article, I begin by presenting a cartography of some of the more extensively investigated forms of multisensory processing, with a special focus on two distinct types of multisensory integration. I briefly discuss the conditions under which these different forms of multisensory processing occur as well as (...) their important perceptual consequences and interrelations. In Part II, I then turn to examining of some of the different possible ways in which the structure of conscious perceptual experience might also be characterized as multisensory. In addition, I discuss the significance of research on multisensory processing and multisensory consciousness for philosophical attempts to individuate the senses. (shrink)

A discussion of the remarkable relation between Saint Francis de Sales, Saint Ignatius Loyola, John XXIII, and the simple but vital ideas of Vatican II.

This chapter contains section titled: A Dilemma for Moderate Constructivism Is the Dilemma Flawed? Intentional Objects Salience Creation as Property Change Can One Escape the Dilemma by Rejecting Bivalence? Indeterminacy and Imputation Historical Constructivism Oeuvres Conclusion Notes.

Over the past five decades, I have been developing a distinctive view of free will according to which it requires that agents be to some degree ultimately responsible for the formation of their own wills. To act ‘of one's own free will’ in this sense is to act ‘from a will’ that is to some extent ‘of one's own free making’. A free will of this ultimate kind has been under attack in the modern era as obscure and unintelligible. In (...) this paper, I discuss the arguments for such a view and compare it to other contemporary views of free will and action. I then address criticisms that such a non‐determinist free will cannot be made intelligible or reconciled with modern science, does not allow sufficient agent control, reduces to mere chance or luck or randomness, leads to various regresses, or fails to account for moral responsibility, among other criticisms. (shrink)

This paper explores the question whether an adequate account of the facts about imagination and mental imagery must construe mental images as objects. Much of the paper is a study of Alastair Hannay's defense of an affirmative answer in his wide?ranging study, Mental Images ? A Defence. The paper first sets out and evaluates Hannay's case. The second part develops an alternative account of mental images, including non?visual images, which Hannay does not treat in detail. The alternative account is analogous (...) to the adverbial theory of perception; and it is suggested how this account, without construing mental images as objects, might accommodate the data from which Hannay argues for their objecthood. (shrink)